Because Rugose and its mammalian ortholog neurobeachin, a gene implicated in autism (Castermans et al., 2003), are localized near the trans-Golgi network (Wang et al., 2000; Volders et al., 2012), effects on synapses and behavior have been proposed to originate from perturbing the somatodendritic compartment (e.g. by affecting Golgi function, postsynaptic receptors and dendritic spines) (Niemann et al., 2011; Volders et al., 2012; Gromova et al., 2018; Repetto et al., 2018). The gene discussed is NBEA; the disease is autism.