Just over half of the proteins showing increased secretion in response to media containing Aβ oligomers (APOE, COL1A1, COL1A2, PCOLCE, PDIA3, PEBP1, PPIA, PPIB, PREP, PREDX1, PTGDS, and SOD3) were identified as altered in AD CSF. This evidence concerns the gene PEBP1 and Alzheimer disease.