Among these proteins increased, we identified known markers of reactive astrocytes such as APOE, vimentin, and SERPINA3N (Escartin et al., 2021; Zamanian et al., 2012), whose expression increases in astrocytes in human AD brains (Viejo et al., 2022), demonstrating the disease relevance of the proteins identified. The gene discussed is VIM; the disease is Alzheimer disease.