SCG5 and Alzheimer disease: While not previously included within the chaperone network (Brehme et al., 2014), secretogranin 5, also known as 7B2, whose levels are reduced in our Aβ‐exposed astrocyte secretome, has also been suggested to function as a chaperone, since it colocalizes with Aβ plaques in human AD brain and prevents fibrillation of Aβ40 and Aβ42 in vitro and blocks their cytotoxic effect in culture (Helwig et al., 2013).