Just over half of the proteins showing increased secretion in response to media containing Aβ oligomers (APOE, COL1A1, COL1A2, PCOLCE, PDIA3, PEBP1, PPIA, PPIB, PREP, PREDX1, PTGDS, and SOD3) were identified as altered in AD CSF. The gene discussed is PTGDS; the disease is Alzheimer disease.