PDIA3 and neuroblastoma: It was detected in human CSF bound to Aβ (Erickson et al., 2005) and, more recently, Di Risola et al. have reported that treating SHSY5Y neuroblastoma cells with synthetic Aβ led to increased extracellular PDIA3, which can bind to Aβ 25–35 in vitro to reduce aggregation and counteract its cellular toxicity (Di Risola et al., 2022).