PPIA and amyotrophic lateral sclerosis: PTGDS synthesizes prostaglandin D2, which functions as a modulator of the inflammatory response (Joo & Sadikot, 2012); peptidylprolyl isomerase A (PPIA) is mainly cytoplasmic but it can also be secreted in response to different inflammatory stimuli such as LPS (Hoffmann & Schiene‐Fischer, 2014), and inhibition of extracellular PPIA reduces neurotoxicity and neuroinflammation markers such as NF‐kB activation in a mouse model of amyotrophic lateral sclerosis (ALS) (Pasetto et al., 2017).