In a study of children with CKD by Mitsnefes et al., plasma fibroblast growth factor 23 (FGF23) was associated with a two-fold greater risk of LVH.10 Because CVD affects the long-term morbidity and mortality of children with CKD, a better understanding of LVH is critical to elucidate its pathophysiology and discover effective treatments.3 Here, FGF23 is linked to chronic kidney disease.