For instance, hsa-miR-143-3p—which affects neutrophil counts mediated by BCL2 expression—has been implicated in numerous immunological diseases such as cancers and ischemic stroke [48-50], has been found to influence inflammatory factors and cell apoptosis [51, 52], and to inhibit Wnt and MAPK signaling [53]. This evidence concerns the gene BCL2 and ischemic stroke.