TP53 and cancer: Using IPA pathway enrichment analysis, we found that the 197 unique genes—pooled across experimentally observed and highly predicted gene targets—were implicated in MYC mediated apoptosis signaling, crosstalk between dendritic cells and natural killer cells, and p53 signaling, among others, and enriched in cancer, infectious disease and immunological disease (Additional file 2: Table S8A–B).