In a rat model of PCOS with levulinic 18 methyl kynurenine in silico capsules, abnormal granulosa cell LncMEG3 expression was sufficient to cause cystic ovarian changes in rats, but the abnormal changes in sex hormone levels and AMH induced by levulinic 18 methyl kynurenine in silico capsules in a rat model of PCOS did not fully account for the clinical manifestations of clinical PCOS, and it has not yet been explored what genes downstream of LncMEG3 targeting regulation are involved. Here, PLXNA3 is linked to polycystic ovary syndrome.