BRD2 and polycystic ovary syndrome: LncMEG3 has been reported to be upregulated in granulosa cells in the levonorgestrel 18 methyl nortriptyline silicone capsule-induced PCOS rat model, and inhibition of LncMEG3 expression by acupuncture can alleviate PCOS, as evidenced by reduced T, LH and FSH secretion, as well as impaired granulosa cell proliferation and autophagy [19].