Since we observed devastating mortality rates of up to 90% in patients with ICH [10], our ECMO centers empirically lowered the anticoagulation target ranges for COVID-19 patients on ECMO support from anti-factor Xa activity (anti-Xa) of 0.3–0.4 U/mL to anti-Xa activity of 0.15–0.3 U/mL. The gene discussed is TNXA; the disease is COVID-19.