Approved systemic JAK inhibitors for AD have a high selectivity as follows: anti-JAK1 (Abrocitinib or ABRO; Upadacitinib or UPA); anti-JAK1/2 (Baricitinib or BARI) and anti-JAK1/3 (Tofacitinib or TOFA).11, 88. This evidence concerns the gene JAK1 and Alzheimer disease.