BRAF and colorectal carcinoma: One study suggested that CD163+ M2 macrophages were markedly increased in BRAF V600E mutant CRC tumor compared to a wild-type tumor (mean ± SD, 8.33 ± 5.93 vs. 3.67 ± 3.02, respectively, P = 0.040), while no difference was exhibited in CD68+ M1 macrophages (mean ± SD, 18.43 ± 13.53 vs. 20.96 ± 15.34, respectively, P = 0.664) [89].