BRAF and malignant colon neoplasm: The authors also identified that colon cancers with BRAF mutant had higher stromal score (P = 0.02), immune score (P < 0.0001), ESTIMATE (Estimation of STromal and Immune cells in MAlignant Tumour tissues using Expression data) score (P = 0.0001), and lower tumor purity (P = 0.0003).