FOXP3 and colorectal neoplasm: Kwak et al. found a significantly higher density of FOXP3+ T cells at the infiltrative margins of BRAF-mutated advanced colorectal tumors (P < 0.001), whereas lower densities of CD4+ and FOXP3+ T cells were significantly lower (P = 0.011 and P < 0.001, respectively) in the center of these tumors [84].