In tissue samples collected from 43 patients with colon cancer, Cen et al. found that BRAF mutation colon cancer had significantly higher expression of PD-L1, PD-1, CTLA4, LAG3, and TIM3, which is consistent with data from 396 colon cancers from TCGA datasets [85]. This evidence concerns the gene HAVCR2 and malignant colon neoplasm.