Interestingly, G6pc overexpression but not HIF-1A silencing dropped down the intracellular lipid content in miR-494-overexpressing Huh-7 cells (Fig. 4B, S7B) highlighting the role of G6pc in miRNA-mediated dysregulation of lipid metabolism in HCC. This evidence concerns the gene G6PC1 and hepatocellular carcinoma.