G6PC1 and hepatocellular carcinoma: Interestingly, rescue experiments with G6pc overexpression vector in miR-494 overexpressing Huh-7 cells, but not in control cells, reverted their 3D phenotype decreasing their size, and activating the apoptotic cascade (Fig. S3F-H), demonstrating that G6pc targeting mediates the biologic effects of miR-494 on 3D cell growth in HCC.