G6PC1 and hepatocellular carcinoma: Notably, rescue experiments with G6pc overexpression vector showed an increase of both basal OCR and ATP-linked respiration in miR-494-overexpressing Huh-7 cells, but not in control cells, reverting their glycolytic metabolism towards OXPHOS respiration, demonstrating miR-494/G6pc axis involvement in metabolic reprogramming of HCC cells (Fig. S5D-G).