REST and digestive system neoplasm: To note, the analysis of this dataset revealed much more aberrations in PA (14,416 altered NRSE) respect to gastrointestinal tumours (approximately 4600 altered NRSE) and CLL (1750 altered NRSE), probably due to REST overexpression in brain tumours, contributing to the dysregulation of REST-mediated mechanism [22, 23].