NR1H3 and atherosclerosis: Of the 265 TFs expressed in DO-F1 liver tissue, eleven genetically regulated TFs were correlated with atherosclerosis, and our results not only suggest that lipid metabolism and inflammatory pathway-related TFs regulate gene expression For example, the liver X receptor alpha (LXRα), encoded by Nr1h3 gene, is an important regulator of cholesterol, fatty acid, and glucose homeostasis44.