Similarly, of 16 genes that have cis-eQTLs at the Chr 19 locus, Pten (phosphatase and tensin homolog) and Cyp2c67 (cytochrome P450, family 2, subfamily c, polypeptide 67) were negatively correlated (P = 0.005) with aortic lesion area in males (Figs. 4A and 5A) and are physically located within the atherosclerosis QTL interval on Chr 19 (Figs. 4B and 5B). Here, PTEN is linked to atherosclerosis.