For example, both tumors were mainly composed of epithelial breast cancer cells (EPCAM+) with a similar distribution of hormone receptors (ERBB2 for HER2, ESR1 for estrogen receptor, and PGR for progesterone receptor) and histology markers (CDH1 for E-cadherin) (Supplementary Fig. 12b, c). Here, ESR1 is linked to breast cancer.