A previous study by our group described, in a cohort of 80 young survivors of childhood acute lymphoblastic leukemia (ALL) (mean age 21.1 years, mean survival time 12.4 years), an altered lipid and apolipoprotein (Apo) composition of HDL2 particles when compared to a control group, suggesting defects in functionality [24, 25]. This evidence concerns the gene AOPEP and acute lymphoblastic leukemia.