As shown in Fig. 1, HDGF sgRNA1 and sgRNA2 significantly inhibited H1975 the cell proliferation (Fig. 1C), colony formation (Fig. 1E, F), and migration and invasion (Fig. 1G, H) abilities (P < 0.01, P < 0.001 vs. control), indicating that HDGF knockdown reduced the malignant properties of NSCLC cells. This evidence concerns the gene HDGF and non-small cell lung carcinoma.