The KMT2D, GNAS, EP300, GRM3, and PIK3CG mutations were all significantly higher in patients with squamous than those with adenocarcinoma (P = 0.0066, P = 0.019, P = 0.0075, P = 0.017, and P = 0.0075, respectively). The gene discussed is PIK3CG; the disease is adenocarcinoma.