KDM5A and acute myeloid leukemia: In particular, around 2% of all pediatric AML patients harbor the chromosomal translocation t(11;12)(p15;p13), that gives rise to the chimeric fusion of the nucleoporin 98 (NUP98) and the KDM5A lysine demethylase, resulting in NUP98-KDM5A fusion protein [10, 11].