Also, consistently with the fact that nearly all patients carrying NUP98-KDM5A protein display complex karyotypes [10, 13, 46], here we demonstrated that NUP98-KDM5A expression contributes to chromosome missegregation Overall, our results identify NUP98-KDM5A mechanisms to induce genomic instability that potentially can drive leukemia evolution (Fig. 7E). This evidence concerns the gene NUP98 and leukemia.