By exploring the relationship between characteristic FRGs and the immune status of patients, we found that the levels of neutrophils in the peripheral blood of ARDS patients were positively correlated with the expression levels of Slc7a11 (Pearson’s R2 = 0.086, p = 0.033) and Slc39a14 (Pearson’s R2 = 0.123, p = 0.008). Here, SLC7A11 is linked to acute respiratory distress syndrome.