Observational data reveals that low circulating DGLA level is associated with total mortality in patients with acute cardiovascular disease and acute decompensated heart failure [36], diabetic retinopathy [37]; while A high serum DGLA level was associated with obesity, body fat accumulation, a high ALT level, and insulin resistance in patients with type 2 diabetes [38]. Here, GPT is linked to obesity due to melanocortin 4 receptor deficiency.