SIRT4 and bladder transitional cell carcinoma: By log-rank test, we found that SIRT4 level, T stage and AJCC stage were factors affecting the overall survival time of BLCA patients (Table 2), and BLCA patients with low SIRT4 levels had worse overall survival time compared with those with high SIRT4 levels (P < 0.01) (Fig. 1E).