The OS analysis results indicated that HOXB9 is associated with poor prognosis for patients with ACC, ESCA, GBM, HNSC, KIRP, KIRC, LGG, LUSC, LUAD, MESO, PAAD, PRAD, READ, SKCM, THYM, UCEC, and UVM, while being a protective factor for patients with KICH. The gene discussed is HOXB9; the disease is adrenal cortex carcinoma.