The potential targets of angelicin in the treatment of OS are shown in Supplementary Table 4, and they were analyzed by KEGG enrichment analysis; the results showed that angelicin impacts osteosarcoma through multiple signaling pathways, such as apoptosis, the p53-related signaling pathway, the NF-kappa B signaling pathway, and the TNF signaling pathway. Here, TP53 is linked to osteosarcoma.