Whereas in previous reports RIOK1 expression was correlated with hormone receptor status and phosphatidylinositol 3-kinase (PI3K)/AKT signaling in breast cancer and glioma,11,13 respectively, no consistent association of RIOK1 mRNA expression with AR and PI3K/AKT target gene sets in PCa was observed. Here, RIOK1 is linked to central nervous system cancer.