RIOK1 is involved in the final steps of pre-40S ribosomal maturation, cell-cycle progression, and protein arginine N-methyltransferase (PRMT)-5 methylosome substrate recruitment.6, 7, 8 Furthermore, pan-cancer screens have indicated that RIOK1 is up-regulated in many cancer entities,9 including lung, breast, and colorectal cancers as well as glioma.10, 11, 12, 13 In addition, RIOK1 overexpression is correlated with tumor stage, therapy resistance, poor survival, and other prognostic risk factors in these malignancies.10, 11, 12, 13, 14, 15. This evidence concerns the gene RIOK1 and colorectal cancer.