Berker et al. (2009) found that a higher amount of Hcy in follicular fluid of PCOS women undergoing oocyte pick-up following FSH stimulation sharply marked lower oocyte quality, fertilization rates, embryo quality, and pregnancy rates with no pregnancies occurring in women whose sampled follicles contained more than 8 μmolar Hcy [13]. The gene discussed is BRD2; the disease is polycystic ovary syndrome.