In mouse models, sitagliptin improved capillary collateralization in the setting of hind limb ischemia (Dai et al., 2018), and DPP4 inhibition has been shown to attenuate endothelial cell loss in the heart following acute myocardial infarction in mice (Kubota et al., 2016). This evidence concerns the gene DPP4 and myocardial infarction.