Heatmap analysis of gene expression in adherent cells and stem‐like tumor spheres (Figure 1D) revealed a negative correlation between YY2 and stem‐related factors, including CD44, SOX9, SALL2, KLF15, OCT4 (also known as POU class 5 homeobox 1 or POU5F1), MYC, ASCL1, and POU3F2. This evidence concerns the gene POU5F1 and neoplasm.