To elucidate the pathological function of the YY2/DRP1 pathway in vivo, especially in regulating tumor‐initiating capacity, we established stable HCC‐LM3/pcCon, HCC‐LM3/pcYY2, and HCC‐LM3/pcYY2/pcDRP1 cell lines (Figure S16A, Supporting Information), and transplanted them subcutaneously into BALB/c‐nu/nu mice. Here, YY2 is linked to hepatocellular carcinoma.