Furthermore, abnormal mitochondrial fission is associated with various pathological conditions, including neurodegenerative disorders, cardiovascular diseases, obesity, and embryonic lethality.[15, 17, 39] Hence, although further studies are needed, the YY2/DRP1 axis could be implicated in multiple biological processes and pathological conditions. This evidence concerns the gene YY2 and obesity due to melanocortin 4 receptor deficiency.