YY2 and neoplasm: CSCs play a pivotal role not only in tumor initiation, but also in therapeutic resistance, metastasis, and recurrence in multiple types of cancers.[32] Asymmetric division, whereby a CSC divides into a cell that maintains its stem cell characteristics and another more differentiated transit‐amplifying cell, is crucial for maintaining the pool of CSCs and their tumor‐initiating potential.[6, 33] Herein, we identified YY2, an activating or inhibitory zinc‐finger transcription factor belonging to the yin‐yang family,[34] as a novel negative regulator of CSCs.