DRP1 colocalization with Tom20 was low in YY2‐overexpressed HCC‐LM3 cells (Figure 5F) and high in YY2 knock‐out cells (Figure 5G) obtained from stem‐like tumor spheres, indicating that YY2 suppressed DRP1 distribution in the mitochondrial network of liver CSCs. This evidence concerns the gene YY2 and hepatocellular carcinoma.