Asymmetric division maintains the pool of CSCs while also generating highly proliferative non‐CSC cells.[5, 6] YY2 overexpression markedly decreased the percentage of CD44High HCC‐LM3 cells (Figure3A); whereas YY2 knock‐out caused a conspicuous increase (Figure 3B). This evidence concerns the gene YY2 and hepatocellular carcinoma.