TRPM7 expression has been demonstrated in rat hepatocyte cell lines, human hepatoma cells and, in vivo, in human hepatocytes but has not been correlated with liver disease [52,53]; therefore, in the present study, we compared, in samples obtained at the time of liver transplantation, the Mg content in liver tissue and the hepatocyte expression of TRPM7 in healthy liver of donors and in hepatic cirrhotic tissue obtained from adult patients. The gene discussed is TRPM7; the disease is hepatocellular carcinoma.