The prevalence of other metabolic alterations such as impaired glucose fasting (IGF), impaired glucose tolerance (IGT), insulin resistance (based on HOMA-IR), hyperuricemia, and hypertriglyceridemia at baseline were more often present in the overweight/obesity group than in the lipedema group (Table 6). The gene discussed is IGF1; the disease is obesity due to melanocortin 4 receptor deficiency.