By increasing the expression of CDH1 (E-cadherin), calcitriol thereby promotes intercellular adhesion, inhibits the rolling of tumour cells and their adhesion to microvascular endothelial cells, i.e., the extravasation stage preceding metastasis, and blocks the CXCL12/CXCR4 chemokine axis [237,238]. Here, CDH1 is linked to neoplasm.