IL1B and neoplasm: Furthermore, calcitriol amplified the levels of the negative regulators of the Wnt/β-catenin pathway TCF7L2 (encoding TCF4), DKK1, and AXIN1; it also antagonised the pathway by reducing the production of IL-1β by TAMs, inhibiting GSK-3β activity in tumour cells, and increasing β-catenin expression.