Importantly, calcitriol also induces increased expression of CDH1 (E-cadherin) and other epithelial markers involved in differentiation, such as ZO-1, and inhibits downstream Wnt/β-catenin signalling targets by blocking transcription of the proto-oncogene c-myc and CCND1 genes (encoded cyclin D1); this prevents the differentiation of tumour cells, a feature that is also involved in angiogenesis, migration, and invasion. This evidence concerns the gene CDH1 and neoplasm.