MTOR and brain ischemia: Treatment with 6-gingerol at a dose of 5 mg/kg in male C57/BL6J mice and doses of 10, 20 and 30 μM of primary microglia from 1-day-old C57/BL6J mice showed improvements in cerebral ischemia injury by suppressing microglia-mediated neuroinflammation by downregulating the Akt-mammalian target of the rapamycin (mTOR)-STAT3 pathway [204].