NFE2L2 and ischemia: In conjunction with taurine, α-pinene (5μg/mL) has been shown through radical scavenging assays to increase Nrf2-dependent activation of antioxidants SOD and GPx1, and CAT antioxidant gene targets [155], while BCP, a CB2R agonist, has also been observed to protect against ischemia-induced oxidative stress through upregulation of Nrf2 and HO-1 expression, as well as increased antioxidant activity of SOD and CAT, and GPx [156,157].