Time-restricted feeding (TRF) can drive and remodel the daily rhythms of many pathways responsible for hepatic glucose and lipid metabolism in terms of gene expression and metabolic processes; however, in mice with whole-body or liver-specific deletion of Bmal1 or other circadian clocks, TRF can reduce the accumulation of hepatic lipids and prevent obesity and metabolic syndrome [14]. The gene discussed is BMAL1; the disease is metabolic syndrome.