Li et al. [47] found that a liver-enriched lncRNA regulator of hyperlipidemia binds directly to heterogeneous nuclear ribonuclear protein U (hnRNPU), and that the hnRNPU can transcriptionally activate Bmal1, leading to the inhibition of VLDL secretion in hepatocytes, and thereby proposing a new functional model of BMAL1 in lipid metabolism. The gene discussed is HNRNPU; the disease is hyperlipidemia.