BMAL1 and obesity due to melanocortin 4 receptor deficiency: Time-restricted feeding (TRF) can drive and remodel the daily rhythms of many pathways responsible for hepatic glucose and lipid metabolism in terms of gene expression and metabolic processes; however, in mice with whole-body or liver-specific deletion of Bmal1 or other circadian clocks, TRF can reduce the accumulation of hepatic lipids and prevent obesity and metabolic syndrome [14].