Moreover, Muñoz-Guardiola and his colleagues reported that the alpha-hydroxylated polyunsaturated fatty acid (ABTL0812) promotes the overexpression of DDIT3 causing tumor-cell apoptosis and that TRIB3 overexpression inhibited the protein kinase B (Akt) and the mammalian target of rapamycin (mTOR) complex 1 (AKT-MTORC1) pathway provoking cell death by autophagy [86]. This evidence concerns the gene DDIT3 and neoplasm.