In obese participants, intramyocellular fat remained unchanged, whereas hepatic fat content decreased from 8.9 ± 3.2 to 5.6 ± 1.8% (p < 0.05) and visceral fat content from 54.7 ± 6.0 to 49.6 ± 5.5 cm2 (p < 0.05). No significant changes were observed in lean participants.  Insulin resistance: Decreased fasting insulin (21.8 ± 2.7 to 18.2 ± 2.4 μ/mL, p < 0.01) and homeostasis model assessment of insulin resistance (HOMAIR) (4.9 ± 0.7 to 4.1 ± 0.6, p < 0.01).No significant changes were observed in lean participants. The gene discussed is INS; the disease is Insulin resistance.