Despite the weak evidence for the benefits of lifestyle interventions on adiposity and BMI outcomes shown in our meta-analysis (pooled BMI mean change = −0.09 (95% CI = −0.19, 0.01, p = 0.09) (Figure 2 and Figure 3), lifestyle interventions were shown to be effective in reducing cardiometabolic NCD risk factors, such insulin sensitivity, metabolic syndrome and blood pressure, in overweight and obese children (Table 2). The gene discussed is INS; the disease is metabolic syndrome.