Higher plasma levels of insulin on their hand entail the development of a certain grade of inflammation, modulated by the adipose tissue and the gut microbiota [5], being also capable to alter fatty acids pathway in the liver: insulin increases lipolysis and promotes de novo lipogenesis, with subsequent elevation of hepatic free fatty acid (FFA) influx, favoring fat accumulation and steatosis progression [6]. This evidence concerns the gene INS and steatosis.