To verify the effects of PC on glucose homeostasis in HFHF-fed mice and reveal the mechanism of PC on improving insulin resistance, the expression levels of two gluconeogen-related genes, phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), in mice liver were determined in this study. The gene discussed is PCK2; the disease is Insulin resistance.