In a 6-hydroxydopamine-induced neurotoxicity Parkinson’s disease model, Sesamum indicum seed extract demonstrated a significant reduction in the activity of antioxidant and non-antioxidant enzymes, such as glutathione reductase, glutathione-S-transferase, glutathione peroxidase, catalase, and glutathione content and thiobarbituric acid reactive substance in the striatum of mice. Here, HPGDS is linked to Parkinson disease.