TH and Parkinson disease: In previous studies in a subchronic mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Mucuna pruriens seed extract was not able to prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced tyrosine hydroxylase reduction or microglia activation [31].