FGF21 decreased in the cohort with obesity (196.34 pg/mL (626.73–1345.86 pg/mL) vs. 108.89 pg/mL (20.7–334.97 pg/mL)) and increased in the normal-weight cohort (101.62 pg/mL (4.7–409.26 pg/mL) vs. 180.3 pg/mL (29.99–396.28 pg/mL), however, these significances were lost after correcting for multiple testing. The gene discussed is FGF21; the disease is obesity due to melanocortin 4 receptor deficiency.