In the current study, we used data from the Trøndelag Health (HUNT) Study, a longitudinal cohort study with a mean follow-up period of 21.8 years [20], to examine whether the consumption of tea and different types of coffee at midlife are associated with long-term risk of AD, MCI, and all-cause dementia, and to also assess the potential impact of sex and ApoE4 carrier status on this association. This evidence concerns the gene APOE and dementia.