APOE and Alzheimer disease: For the ApoE4 sub-analyses and the analyses on AD/MCI risk, boiled coffee, and other types of coffee, we respectively excluded participants with missing data on the ApoE4 carrier status (n = 368), participants with other causes of cognitive impairment apart from MCI and AD (n = 417), participants who drank other types of coffee (n = 4561), and participants who drank boiled coffee (n = 3368).