In patients with NAFLD, Kullman et al. [58] measured the impact of a short-term, one-week high-intensity exercise program and found that while GLP-1 level remained unchanged, exercise instead reversed the GLP-1 resistant state of NAFLD by restoring the normal physiologic response of GLP-1 to glucose stimulation. This evidence concerns the gene GLP1R and metabolic dysfunction-associated steatotic liver disease.