Batatinha et al. [108] demonstrated that after eight weeks of treadmill training, PPAR-α knockout mice that were fed a high-fat diet to induce NAFLD still experienced a decrease in fat accumulation, perhaps owing to changes in PPAR-γ activity and fatty acid oxidation in the skeletal muscle, which has previously been reported to increase with exercise training in animal models of NAFLD [109,110]. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.