In terms of patients with NAFLD, a recent study by Takahashi et al. [47] found that after 12 weeks of resistance training in which participants performed push-ups and squats three times a week on non-consecutive days, serum FGF-21 level was significantly reduced, confirming the results seen with aerobic exercise training in animal models of NAFLD. Here, FGF21 is linked to metabolic dysfunction-associated steatotic liver disease.