Approximately 200 g of hazelnuts per day, added as a supplement to the diet, achieve the recommended daily fiber intake of 25–35 g/day [17] and have beneficial effects in patients with chronic degenerative diseases such as diabetes, hyperlipidemia, and obesity by controlling glucose, insulin, triglycerides, and cholesterol levels (absent in hazelnuts) by promoting satiety and interfering with carbohydrates and fats adsorption; moreover, this control is a benefit for preventing the onset of diabetes, cardiovascular diseases, and colon cancer [17,18]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.