AGT and diabetic cardiomyopathy: Upregulation of these antioxidant factors (Nrf2, HO-1, and NQO-1) by kaempferol was observed in various models of heart disease, including diabetic cardiomyopathy [11,13], high-glucose-induced cardiomyocyte injury [13], and Ang-II-induced cardiomyocyte hypertrophy [6].