ACE and hypertensive disorder: Substituting ACE inhibitors for ARBs in diabetic patients experiencing ACE inhibitor-related side effects, such as dry cough and angioedema, is recommended [8]; however, the researchers in this field, especially those specializing in ACE inhibition in hypertension, should focus more sharply on the real need of the patients so that patients can benefit from ACE inhibition and experience no, fewer, or tolerable side effects.