STAT3 and neoplasm: Conversely, Choudhari et al. [42] noted a decrease in phosphorylated AKT (pS473-AKT) at concentrations of atiprimod ranging from 0.5 to 5 μM in other signaling pathways that determine tumor development, such as JAK-STAT3 and PI3K/Akt [7,11,42].