LGALS3 and neoplasm: In their work, the authors mentioned that the collagenases MMP-2 and -9 are determining factors in the invasion process due to their ability to degrade the basement membrane of tumor cells, owing to their affinity for collagen types IV, V, VII, X, and XIV; gelatin; elastin; galectin-3; and fibronectin [32,33,34,35].