NR1H4 and metabolic dysfunction-associated steatohepatitis: In a recent study, Shu et al. have shown that Bbr alleviates nonalcoholic steatohepatitis in mice by modulating the interaction of the gut microbiota and bile acid metabolism, and by activating the intestinal Farnesoid X Re-ceptor (FXR), which is a bile acid receptor which thus regulates metabolism of bile acids and the gut microbiota [70] (see also chapter 7).