Particularly in obese and overweight individuals with IR, adipose cells hypersecrete several adipocytokines, such as tumor necrosis factor alpha (TNF-ɑ), resistin and interleukin-6 (IL-6), which chronically promote vascular inflammation by stimulating the development of atherosclerosis and aggravating endothelial dysfunction [20,21]. The gene discussed is IL6; the disease is endothelial dysfunction.