A study showed that two synthesized pyridazin-3(2h)-one derivatives, 5-(5-Propoxybenzo[b]furan-2-ylmethyl)-6-methylpyridazin-3(2H)-one and 5-[(7-Chlorobenzo[b]furan-2-yl)methyl]-6-methylpyridazin-3(2h)-thione, induced cell apoptosis via oxidative stress in a P815 murine mastocytoma cell line by deregulating the redox homeostasis due to the intracellular ROS hyper generation through significant loss of glutathione reductase and thioredoxin reductase activities [38]. The gene discussed is PRDX5; the disease is mastocytoma.