RIOK1 and neoplasm: Data in the Achilles project database demonstrate that the “essentiality” for RIOK1 expression differs between the various CRC MSI-High cell lines in a CRISPR/Cas9 screen (https://portals.broadinstitute.org/achilles (accessed on 21 May 2023)), further supporting our hypothesis that some tumor cells are reliant on RIOK1 expression (Figure 2).