Studies have shown that the efficacy of BM in the treatment of RA is even better than that of traditional NSAIDs such as dexamethasone in certain circumstances, possibly due to the combined effects of NO depletion, CO-mediated inactivation of iNOS and heme oxygenase-1 (HO-1) activation [92]. The gene discussed is HMOX1; the disease is rheumatoid arthritis.