SPP1 and inflammatory bowel disease: In addition to that, five miRNAs (miR-124-3p, miR-34a-5p, miR-1-3p, miR-7-5p, and miR-99b-5p) were found in human cells that might target four hub genes (CXCL2, MMP9, SPP1, and SRC), which are related to inflammatory bowel disease (IBD) and hepatocellular carcinoma (HCC) [89].