TNF and Anorexia: IL-6 level is elevated in cancer, and the progestins MA and MPA decrease it, which shows their anti-cachectic effect, since it is assumed that features of CACS (cancer-related anorexia/cachexia syndrome) can be reproduced in vivo by the chronic administration of pro-inflammatory cytokines, including interleukin-I (IL-I), IL-6, and TNFα, either alone or in combination [24].