Among them, compound 46 showed excellent inhibition against MEK1 (IC50 = 0.015 nM) and PI3K (IC50 = 191 nM) and displayed a 95% and 67% inhibition of tumor ERK1/2 and Akt phosphorylation, respectively, at 2 h postadministration. The gene discussed is MAPK3; the disease is neoplasm.